3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro
3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro-
CAS: 878671-96-6
Molecular Formula: C15H14N4S
3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro - Names and Identifiers
3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro - Physico-chemical Properties
| Molecular Formula | C15H14N4S |
| Molar Mass | 282.36 |
| Density | 1.52±0.1 g/cm3(Predicted) |
| Boling Point | 475.2±38.0 °C(Predicted) |
| pKa | 8.22±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro - Introduction
3H-1,2,4-Triazo-3-thione, 5-amino-4-()-2,4-dihydro- (also known as 3H-1, 2,4-thiazole-3-thiol 5-amino-4-(4-cyclopropyl-1-naphthalene)-2,4-dihydro) is an organic compound with the chemical formula C17H15N3S.
The following is a description of the properties, uses, preparation methods and safety information of the compound:
Nature:
1. Appearance: 3H-1,2,4-Triazole-3-thione, 5-amino-4-(amino)-2,4-dihydro-white or light yellow solid.
2. Solubility: The compound is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM), but poorly soluble in water.
Use:
1. Anticancer activity: The compound has anti-tumor activity and can be used as an intermediate for the development of anti-cancer drugs.
2. Fluorescent probe: Due to the fluorescent properties of the compound in organic solvents, it can be used in the fields of biological imaging and the preparation of fluorescent probes.
Preparation Method:
The synthesis of 3H-1,2,4-Triazole-3-thione, 5-amino-4-(azo)-2,4-dihydro-can be carried out by the following steps:
1. The benzoyl thiourea (Benzoylthiourea) and caprohydantoin (Hexahydro-1H-1,3-diazin-2-imine) react to obtain dihydrothiazole-3-thiol.
2. The dihydrothiazole-3-thiol obtained by the reaction is reacted with 4-cyclopropyl-1-naphthyl halide, and cyclopropyl and naphthyl are introduced by Suzuki-Miyaura coupling reaction.
3. Finally, the synthesized compound is reacted with ammonia to obtain the target product 3H-1,2,4-Triazole-3-thione, 5-amino-4-(pyridine)-2,4-dihydro-.
Safety Information:
1. The compound should be kept away from open flames and high temperatures, and avoid contact with air and moisture.
2. in the process of operation, should wear appropriate protective measures, such as experimental glasses, gloves and laboratory coat.
3. When using or handling the compound, care should be taken to prevent it from entering the eyes, skin and respiratory tract. In case of any discomfort, seek medical attention in time.
The following is a description of the properties, uses, preparation methods and safety information of the compound:
Nature:
1. Appearance: 3H-1,2,4-Triazole-3-thione, 5-amino-4-(amino)-2,4-dihydro-white or light yellow solid.
2. Solubility: The compound is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM), but poorly soluble in water.
Use:
1. Anticancer activity: The compound has anti-tumor activity and can be used as an intermediate for the development of anti-cancer drugs.
2. Fluorescent probe: Due to the fluorescent properties of the compound in organic solvents, it can be used in the fields of biological imaging and the preparation of fluorescent probes.
Preparation Method:
The synthesis of 3H-1,2,4-Triazole-3-thione, 5-amino-4-(azo)-2,4-dihydro-can be carried out by the following steps:
1. The benzoyl thiourea (Benzoylthiourea) and caprohydantoin (Hexahydro-1H-1,3-diazin-2-imine) react to obtain dihydrothiazole-3-thiol.
2. The dihydrothiazole-3-thiol obtained by the reaction is reacted with 4-cyclopropyl-1-naphthyl halide, and cyclopropyl and naphthyl are introduced by Suzuki-Miyaura coupling reaction.
3. Finally, the synthesized compound is reacted with ammonia to obtain the target product 3H-1,2,4-Triazole-3-thione, 5-amino-4-(pyridine)-2,4-dihydro-.
Safety Information:
1. The compound should be kept away from open flames and high temperatures, and avoid contact with air and moisture.
2. in the process of operation, should wear appropriate protective measures, such as experimental glasses, gloves and laboratory coat.
3. When using or handling the compound, care should be taken to prevent it from entering the eyes, skin and respiratory tract. In case of any discomfort, seek medical attention in time.
Last Update：2024-04-09 21:04:16
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CAS: 878671-96-6
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